Saturday, October 29, 2011
Hall 1-2 (San Jose Convention Center)
Marine derived natural products exhibit structurally interesting compounds of biomedical importance [1]. Crude extracts from the marine invertebrate-derived fungus Malbranchea graminicola have shown both antibacterial and antiviral properties. The focus of this project is to identify the small molecules causing antiviral activity. The crude mixtures were fractionated into several purified compounds using high performance liquid chromatography. Mass spectrometry and nuclear magnetic resonance spectroscopy were used to identify the structures of these purified compounds. We expect to present the structures of isolated compounds along with the bioactivity properties of the fractionated extract.