Isolation of Two Novel Cyclic Tetrapeptides from Marine Derived Aspergillus ochraceopetaliformis

Natural products from marine sources have been found to play an important role in anti-cancer research. Sediment was collected off the Kona coast of Hawaii using SCUBA; Aspergillus ochraceopetaliformis was later isolated from this sample.  Analysis of crude extracts gave evidence of novel chemistry. Two novel cyclic tetrapeptides were isolated using LCMS and HPLC. After isolation the two compounds were identified by NMR. Samples will be sent to Josephine Ford Cancer Center (JFCC) and Gilead Sciences to test for possible anti-cancer and human rhinovirus (HRV) activity.