Dose Response Study of Fructose on Cardiovascular Disease Risk Factors

High fructose corn syrup (HFCS) has replaced half of the sugar calories consumed in the United States. Recently, the USDA’s Dietary Guidelines for Americans and the American Heart Association’s Nutrition Committee released recommendations for sugar intake that conflict. One advises Americans to consume sugar at 25% of total intake, while the other advises people to consume sugar at 5% of total intake. As a result, this conflict inspired the investigation of adverse health effects from HFCS. They were compared to the effects of glucose and fructose. This investigation was run by the University of California Davis and known as the Dose Response Study (DRS). This investigation was conducted in academic research laboratories and research laboratory clinics. The subjects were fed balanced diets containing 24% of total energy requirements as fructose, glucose, or HFCS. The subjects participated for two weeks and the results collected suggest HFCS increases dyslipidemia. Dyslipidemia is a risk factor under Metabolic Syndrome. Some of the key indices that promote this risk are Triglycerides, Apo lipoprotein B, Apo lipoprotein A, Low Density Lipoprotein, High Density Lipoprotein, and cholesterol. These key indices significantly increased in response to a high fructose corn syrup diet. This conclusion is vital to the progression of public health. It is important to recognize the adverse health effects of fructose consumption since it accounts for a significant portion of the calories Americans consume.