Genetic Cluster Analysis and Association of Type 2 Diabetes with 124 SNPs in Mexican Families

Latinos develop type 2 diabetes twice as frequently as non-Hispanic Whites. We have analyzed genetic data for 124 Single-Nucleotide Polymorphisms (SNP) across the genome in a Mexican mestizo population. Population structure and association studies were performed for 96 individuals with type 2 diabetes and their relatives from an independent population sample from Monterrey, Mexico. A subset of 62 ancestry informative makers (AIM) and a subset of 62 SNPs associated with type 2 diabetes reported in literature were used to evaluate the population genetic structure of the sample population. Population structure patterns were examined among this geographical Mexican population to determine if samples from them could be merged for future population-based disease-gene association studies of type 2 diabetes.